Natural antisense transcripts as therapeutic targets
نویسندگان
چکیده
منابع مشابه
Natural antisense transcripts.
Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously thought to be 'junk DNA'. Roughly defined ...
متن کاملNATsDB: Natural Antisense Transcripts DataBase
Natural antisense transcripts (NATs) are reverse complementary at least in part to the sequences of other endogenous sense transcripts. Most NATs are transcribed from opposite strands of their sense partners. They regulate sense genes at multiple levels and are implicated in various diseases. Using an improved whole-genome computational pipeline, we identified abundant cis-encoded exon-overlapp...
متن کاملNatural antisense transcripts of Trifolium repens dehydrins
The recently described complex nature of some dehydrin-coding sequences in Trifolium repens could explain the considerable variability among transcripts originating from a single gene.1 For some of the sequences the existence of natural antisense transcripts (NAT s), which could form sense-antisense (SAS) pairs, was predicted. The present study demonstrates that cis-natural antisense transcript...
متن کاملThe functions of natural antisense transcripts.
NATs (natural antisense transcripts) are widespread in eukaryotic genomes. Experimental evidence indicates that sense and antisense transcripts interact, suggesting a role for NATs in the regulation of gene expression. On the other hand, the transcription of a gene locus in both orientations and RNA hybrid formation can also lead to transcriptional interference, trigger an immune response or in...
متن کاملNatural antisense transcripts of Trifolium repens dehydrins
Dehydrins (group 2 LEA proteins) tend to accumulate late in embryogenesis and in response to stress leading to cell dehydration (e.g., drought, low temperature, and salinity). The expression pattern of group 2 LEA genes is frequently associated with higher tolerance of crop plants to abiotic stresses such as cold and drought. All dehydrins have at least one conserved, lysine-rich 15-amino acid ...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Therapeutic Strategies
سال: 2013
ISSN: 1740-6773
DOI: 10.1016/j.ddstr.2013.03.001